Table 2.

Patient characteristics and results of previous infertility treatments in patients diagnosed with deficient oocyte maturation, defined as at least one previous ART cycle with no mature oocytes or at least two previous ART cycles with 80% or more immature oocytes at oocyte retrieval. Patient 25 and patient 26 are sisters

			Oocyte maturation abnormalities
Patient No.	Age	Type of infertility	BMI (kg/m2)	Basal AFC	AMH (μg/L)	Previous infertility treatment: stimulation protocols	Previous infertility treatment: ovulation trigger	MII oocytes retrieved in ART cycles*	Good-quality embryos
10	31	Primary	25.2	13	6.11	1st cycle GnRH antagonist; 2nd cycle long GnRH agonist	10,000 IU hCG trigger (2 cycles)	Yes	Yes
11	31	Primary	21.4	13	1.72	3 GnRH antagonist cycles; 1 long GnRH agonist cycle	10,000 IU hCG trigger (4 cycles)	No	No
12	26	Primary	24.0	6	0.99	2 GnRH antagonist cycles; 1 long GnRH agonist cycle	10,000 IU hCG trigger (3 cycles)	Yes	No
13	34	Primary	26.4	28	3.33	13 cycles (GnRH antagonist and long GnRH agonist)	10,000 IU hCG trigger (13 cycles)	Yes	Yes
14	33	Primary	21.0	8	1.10	2 cycles (no details available)	No details available	No	No
15	28	Primary	22.0	12	2.79	3 long GnRH agonist cycles	10,000–15,000 hCG trigger	Yes	No
16	26	Primary	32.2	24	3.02	3 cycles (no details available); 4th cycle GnRH antagonist	hCG trigger (3 cycles); 4th cycle 10,000 IU hCG + 0.3 mg triptorelin	Yes	Yes
17	35	Primary	23.2	15	5.13	2 cycles (no details available); 3rd cycle GnRH antagonist; 4th cycle long GnRH agonist	No details available (2 cycles); 3rd cycle 0.2 mg triptorelin; 4th cycle 10,000 IU hCG	Yes	No
18	36	Primary	25.6	15	3.26	3 GnRH long agonist cycles	10,000–20,000 IU hCG	Yes	No
19	33	Primary	23.7	18	1.87	2 GnRH antagonist cycles; 1 long GnRH agonist cycle	10,000 IU hCG	No	No
20	32	Primary	23.0	13	3.26	4 cycles (short and long GnRH agonist)	hCG trigger	No	No
21	33	Primary	22.0	24	3.73	3 cycles (no details available)	hCG trigger	Yes	No
22	31	Primary	20.3	40	4.6	3 cycles (no details available)	No details available	No	No
23	24	Primary	22	45	7.45	4 cycles (no details available)	No details available	No	No
24	21	Primary	22.8	11	3.81	3 GnRH long agonist cycles	hCG trigger	No	No
25	31	Primary	19.2	13	U	1 GnRH antagonist cycle; 1 long GnRH agonist cycle	10,000 IU hCG trigger	Yes	No
26	31	Primary	24.1	29	8.12	1 GnRH short agonist cycles	10,000 IU hCG trigger	No	No
27	36	Primary	21.7	20	1.5	several cycles, different protocols	hCG trigger	No	No
28	25	Primary	24.3	14	3.5	5 cycles, different protocols	hCG trigger	Yes	Yes

AFC, antral follicle count; AMH, anti-Müllerian hormone; ART, assisted reproductive technologies; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization; MII, mature oocytes