Fig. 2.

Schematic representation of promoter 1.1 of CYP19A1 bovine gene and associated TFBSs. DICE (downstream immunoglobulin control element), EVI1 (ecotropic virus integration site-1), GATA (family of transcriptional regulatory proteins), GREF (androgen receptor family), PCBE/PREB (prolactin regulatory element-binding protein), and RXRF (retinoid X receptor family). a Promoter structure without mutation effect. b Core promoter structure with new transcription binding sites created due to SNP rs41651668 T > C. c DNA sequences recognized by transcription factor families surrounding the second transcription start site (TSS-2). Nucleotides in red color denote the mutation site. Nucleotides in capitals denote the core sequence used by MatInspector (modified output of Genomatix-MatInspector software)