Table 2.
Regions showing significant differences in effective connectivity in aMPFC between any pairs of three groups.
| Regions | BA | MNI coordinates |
Cluster | t | AVHs (mean) | Non-AVHs | HCs | ||
|---|---|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||||
| aMPFC→Other regions | |||||||||
| Non-AVHs vs. HCs | |||||||||
| Right cingulate gyrus | 23 | 6 | -27 | 33 | 82 | -3.63 | 0.02 | 0.11 | |
| Left insula | 13 | -30 | -6 | 12 | 87 | -5.52 | -0.03 | 0.01 | |
| AVHs vs. HCs | |||||||||
| Left cingulated gyrus | 24 | 0 | -6 | 45 | 124 | -4.66 | 0.01 | 0.07 | |
| Left inferior temporal gyrus | 20 | -57 | -18 | -33 | 144 | -3.90 | -0.01 | 0.02 | |
| AVHs vs. non-AVHs | |||||||||
| Left inferior temporal gyrus | 20 | -42 | -24 | -30 | 86 | -4.18 | -0.01 | 0.03 | |
| Other regions→aMPFC | |||||||||
| Non-AVHs vs. HCs | |||||||||
| Left cingulate gyrus | 23 | -3 | -21 | 21 | 78 | 4.26 | -0.02 | -0.07 | |
| Right putamen | – | 18 | 3 | 0 | 80 | 4.62 | -0.02 | -0.09 | |
| Right thalamus | – | 17 | |||||||
| AVHs vs. HCs | |||||||||
| Right middle frontal gyrus | 8/9 | 33 | 30 | 54 | 90 | 3.76 | 0.08 | -0.04 | |
| Right thalamus | – | 3 | -3 | 3 | 81 | 4.17 | -0.02 | -0.10 | |
| Right putamen | – | 10 | |||||||
| Left cerebellum posterior lobe | – | -45 | -69 | -39 | 79 | 3.96 | -0.07 | -0.09 | |
| AVHs vs. non-AVHs | |||||||||
| None | |||||||||
PCC, posterior cingulate cortex. aMPFC, anteromedial prefrontal cortex. AVHs, auditory verbal hallucinations. HCs, healthy controls.