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. 2018 Dec 5;12:896. doi: 10.3389/fnins.2018.00896

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Copyright © 2018 Lukiw, Cong, Jaber and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Progressive association and envelopment of AD-affected neocortical neuronal nuclei by LPS (red stain; λ_max = 690 nm), DAPI (blue nuclear stain; λ_max = 470 nm) and NeuN (neuron-specific green stain; λ_max = 520 nm); human superior temporal lobe AD neocortex (Brodmann A22) from CDR (clinical dementia rating) 1.0, 2.0 and 3.0 AD brains; A,B = CDR 1.0; C,D = CDR 2.0; E,F = CDR 3.0 (see also https://knightadrc.wustl.edu/cdr/cdr.htm); LPS staining (red) was subjected to co-localization analysis with the neuronal marker NeuN (green) and/or nuclear marker (blue); magnification 63×; scale bar = 20 μm.