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. 2018 Dec 5;6:378. doi: 10.3389/fped.2018.00378

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Copyright © 2018 Ragab, Viehweger, Bauer, Geyer, Yang, Seils, Belharazem, Brembeck, Schildhaus, Marx, Hahn and Simon-Keller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of FH535, XAV939, ß-catenin siRNA, or WNT3A on proliferation of RMS cell lines. (A) qRT-PCR of the ß-catenin-target genes MYC (white bars) and BIRC5 (black bars) after incubation with FH535 (40 μM), XAV939 (16 μM), ß-catenin siRNA, or WNT3A conditioned medium for 48 h. GAPDH was used for normalization. Shown is the mean and SEM of three independent experiments measured in duplicates and compared to the solvent control. (B) represents MTT test to examine the influence of 40 μM FH535, 16 μM XAV939, ß-catenin siRNA, or conditioned WNT3A Medium on metabolic activity of the ARMS cell lines CRL2061 and FLOH1 and the ERMS cell line RD over 72 h. DMSO and scrambled siRNA served as control (ctr). The graphs show one out of three experiments, measured in triplicates.