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. 2018 Dec 11;9:5279. doi: 10.1038/s41467-018-07685-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — RP-Mps in the adult spleen are crucial for the regeneration of DCs after activation-induced depletion in vivo. a Schematic outline of the experiment. b Plot shows the depletion of blood monocytes 22 h after injection of chlodronate-coated liposomes (Clod). SD is shown. c Plot shows blood monocyte regeneration 4 weeks after Clod injection. SD is shown. d, e Plots show normal frequencies of spleen macrophages (d) and DCs (e) 4 weeks after Clod injection. SD is shown. f Plot shows reduced frequencies of spleen RP-Mps 4 weeks after Clod injection. SD is shown. g Histograms show the expression of CD86 on spleen DCs 6 h after injection of LPS in indicated test groups. h, i Plots show the frequencies of DCs in mice that have or have not received Clod 4–5 weeks before and that were injected with LPS 2 (h) or 7 (i) days before. Data are pooled from three independent experiments. Two-sided t tests were performed and SD is shown throughout the figure. SD are shown