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. 2019 Jan;368(1):41–49. doi: 10.1124/jpet.118.251199

Fig. 2.

Fig. 2.

Pimavanserin suppresses cue reactivity on FA day 30, but not FA day 1, from cocaine self-administration. (A) Total presses (mean ± S.E.M.) on the active (white circles) or inactive lever (black circles; left y-axis), and total number of cocaine infusions (mean ± S.E.M.) obtained (gray circles; right y-axis) are presented for the acquisition and maintenance phase of cocaine self-administration. (B) Previously active and inactive lever presses (mean ± S.E.M.) are presented for the cue reactivity test session in VEH-treated rats on FA day 1 and FA day 30 from cocaine self-administration. Cue reactivity is significantly elevated on FA day 30 vs. FA day 1 from cocaine self-administration (*P < 0.05; n = 11 or 14/group). The effects of pimavanserin (0.3, 1, 3, 10 mg/kg) on previously active and inactive lever presses (mean ± S.E.M.) on (C) FA day 1 (n = 12–15/group) or (D) FA day 30 (n = 11–12/group) from the last cocaine self-administration session are presented. Pimavanserin suppressed previously active, but not inactive, lever presses on FA day 30 from cocaine self-administration (*P < 0.05 vs. VEH).