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. 2019 Jan;368(1):41–49. doi: 10.1124/jpet.118.251199

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Fig. 3. — Baseline levels of impulsive action predict the efficacy of pimavanserin to suppress cocaine cue reactivity on FA day 30 from cocaine self-administration. Target premature responses under an ITI5 schedule in the 1-CSRT task (mean ± S.E.M.) are presented on the x-axis, and previously active lever presses (mean ± S.E.M.) on the cue reactivity test session are presented on the y-axis. The relationship between target premature responses and previously active lever presses after pretreatment with VEH or pimavanserin (PIM; 0.3, 1, 3, 10 mg/kg) is represented by a linear regression line for each pretreatment condition. (A) Target premature responses predicted the number of previously active lever presses exhibited on FA day 1 and on FA day 30 in VEH-treated rats (F_(1,22) = 5.081, P < 0.05). (B) No relationship was found between target premature responses and the number of previously active lever presses exhibited on FA day 1 after pretreatment with vehicle or pimavanserin (F_(4,62) = 0.405; n.s.). (C) Target premature responses predicted the number of previously active lever presses exhibited on FA day 30 after pretreatment with vehicle or pimavanserin (F_(4,52) = 4.04, P = 0.05).