TABLE 1.

1-CSRT task descriptive statistics for M100907 and pimavanserin pretreatment (mean ± S.E.M.)

Pretreatment	Dose	Premature Responses			Reinforcers Earned	% Accuracy	% Omissions	Latency to First Response (s)	Time to Finish 1-CSRT Task (s)
		Target	Nontarget	Total
M100907	Vehicle	21.8 ± 1.27	1.61 ± 0.265	23.4 ± 1.43	68.4 ± 1.33	97.0 ± 0.433	6.15 ± 0.817	s 3.38 ± 1.85	872 ± 15.9
	0.001 mg/kg	20.5 ± 2.30	1.91 ± 0.719	22.4 ± 2.32	69.5 ± 1.06	97.1 ± 0.674	6.00 ± 1.95	1.00 ± 0.185	874 ± 23.7
	0.01 mg/kg	15.5 ± 2.71	0.818 ± 0.325	16.4 ± 2.88	71.2 ± 2.60	97.5 ± 0.483	10.6 ± 2.83	2.88 ± 1.49	938 ± 40.6
	0.1 mg/kg	11.9 ± 2.87*	1.36 ± 0.338	13.3 ± 2.86*	66.8 ± 2.12	97.7 ± 0.750	18.3 ± 2.70*	2.17 ± 0.862	1022 ± 35.8*
Pimavanserin	Vehicle	17.7 ± 1.44	0.963 ± 0.286	18.6 ± 1.50	73.6 ± 1.40	97.5 ± 0.704	5.89 ± 0.957	1.44 ± 0.258	859 ± 11.5
	0.3 mg/kg	8.22 ± 1.88*	1.00 ± 0.441	9.22 ± 2.09*	79.6 ± 2.06	98.4 ± 0.631	9.89 ± 1.96	0.613 ± 0.161	898 ± 25.9
	1 mg/kg	6.89 ± 1.11*	0.333 ± 0.167	7.22 ± 1.16*	77.2 ± 3.36	98.3 ± 0.674	14.1 ± 3.85*	1.16 ± 0.378	948 ± 41.9*
	3 mg/kg	6.33 ± 1.47*	0.667 ± 0.236	7.00 ± 1.53*	74.4 ± 4.11	98.3 ± 0.657	17.1 ± 4.74*	1.51 ± 0.236	984 ± 46.0*

^*P < 0.05 vs. Vehicle in each respective group.