TABLE 2.

1-CSRT task descriptive statistics and results of two-way analysis of variance (ANOVA)

Forced Abstinence (FA) Day	Pimavanserin Pretreatment	Premature Responses			Reinforcers Earned	% Accuracy	% Omissions	Latency to First Response (s)	Time to Finish 1-CSRT Task (s)
		Target	Nontarget	Total
Descriptive statistics FA day 1	Vehicle	25.7 ± 2.33	1.43 ± 0.327	27.1 ± 2.26	62.7 ± 1.91	98.6 ± 0.377	9.29 ± 1.98	1.16 ± 0.370	981 ± 49.4
	0.3 mg/kg	25.5 ± 2.00	2.00 ± 0.467	27.5 ± 2.21	61.6 ± 2.36	98.3 ± 0.530	9.77 ± 1.86	1.02 ± 0.221	953 ± 24.4
	1 mg/kg	21.1 ± 2.25	1.40 ± 0.306	22.5 ± 2.19	65.2 ± 1.89	98.1 ± 0.371	11.1 ± 1.47	1.17 ± 0.347	948 ± 32.4
	3 mg/kg	24.4 ± 2.05	1.21 ± 0.318	25.6 ± 2.11	65.9 ± 2.64	98.5 ± 0.597	7.57 ± 1.34	1.03 ± 0.171	912 ± 22.6
	10 mg/kg	27.7 ± 1.76	2.00 ± 0.357	29.7 ± 1.76	61.9 ± 1.85	96.8 ± 0.895	6.58 ± 0.839	1.32 ± 0.241	948 ± 31.8
FA day 30	Vehicle	26.2 ± 2.28	2.27 ± 0.384	28.5 ± 2.33	60.4 ± 1.91	97.8 ± 0.702	9.91 ± 1.09	1.15 ± 0.299	984 ± 42.6
	0.3 mg/kg	26.9 ± 2.33	1.67 ± 0.541	28.6 ± 2.06	63.4 ± 2.09	98.7 ± 0.568	7.17 ± 1.24	1.57 ± 0.307	935 ± 26.5
	1 mg/kg	28.5 ± 2.51	1.36 ± 0.432	29.9 ± 2.71	56.9 ± 2.09	97.5 ± 0.601	11.8 ± 2.42	1.37 ± 0.432	977 ± 44.2
	3 mg/kg	20.5 ± 2.28	1.17 ± 0.322	21.7 ± 2.51	66.5 ± 3.29	98.4 ± 0.783	10.9 ± 2.25	1.55 ± 0.469	972 ± 37.2
	10 mg/kg	28.3 ± 2.63	1.00 ± 0.275	29.3 ± 2.80	64.1 ± 1.96	99.2 ± 0.323	6.08 ± 1.52	14.6 ± 10.8	943 ± 42.2
Results of two-way ANOVA
FA day		F(1,116) = 0.716	F(1,116) = 0.208	F(1,116) = 0.563	F(1,116) = 0.671	F(1,116) = 0.509	F(1,116) = 0.087	F(1,116) = 1.96	F(1,116) = 0.358
Pretreatment		F(4,116) = 1.63	F(4,116) = 1.06	F(4,116) = 1.87	F(4,116) = 1.53	F(4,116) = 0.513	F(4,116) = 2.26	F(4,116) = 1.63	F(4,116) = 0.451
FA day x pretreatment		F(4,116) = 1.66	F(4,116) = 1.36	F(4,116) = 1.63	F(4,116) = 1.75	F(4,116) = 2.18	F(4,116) = 0.787	F(4,116) = 1.52	F(4,116) = 0.373