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. 2018 Dec 5;2(23):3447–3461. doi: 10.1182/bloodadvances.2018022053

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graphic file with name advances022053f7-1.jpg — Transcriptional regulation of HSPC-supportive stromal genes in primary MSCs treated with AZA. Primary healthy and MDS MSCs were treated with AZA (10 µM) once or left untreated. After 4 days, MSCs were harvested and expression of selected stromal HSPC-supportive genes was validated by comparative RT-PCR. (A) Selected hub genes of the brown module (ECM receptor interaction, from Figure 6C). (B) Seven collagens differentially expressed between untreated healthy and MDS MSCs (from Figure 6D). (C) Other stromal HSPC-supportive genes differentially expressed between untreated healthy and MDS MSCs (from Figure 6D, in red). *P < .05; **P < .01; ***P < .001; ****P < .0001.

graphic file with name advances022053f7-2.jpg — Transcriptional regulation of HSPC-supportive stromal genes in primary MSCs treated with AZA. Primary healthy and MDS MSCs were treated with AZA (10 µM) once or left untreated. After 4 days, MSCs were harvested and expression of selected stromal HSPC-supportive genes was validated by comparative RT-PCR. (A) Selected hub genes of the brown module (ECM receptor interaction, from Figure 6C). (B) Seven collagens differentially expressed between untreated healthy and MDS MSCs (from Figure 6D). (C) Other stromal HSPC-supportive genes differentially expressed between untreated healthy and MDS MSCs (from Figure 6D, in red). *P < .05; **P < .01; ***P < .001; ****P < .0001.