Table 1.
IC50 values for LCL-161 in a panel of lymphoma cell lines
| Cell line | IC50 value, μM | Lymphoma type |
|---|---|---|
| Daudi | 23.99 | BL |
| Raji | >50 | BL |
| Raji 2R | 48.77 | BL |
| Raji 4RH | 37.95 | BL |
| Ramos | 29.05 | BL |
| RL | 46.55 | GCB-DLBCL |
| RL 4RH | 43.76 | GCB-DLBCL |
| HT | 49.47 | GCB-DLBCL |
| SU-DHL-4 | 35.33 | GCB-DLBCL |
| WSU-DLCL2 | 0.22 | GCB-DLBCL |
| Karpas 422 | 16.12 | GCB-DLBCL |
| U2932 | 43.5 | ABC-DLBCL |
| U2932 4RH | 49.78 | ABC-DLBCL |
| Granta-519 | >50 | MCL |
| Mino | 41.74 | MCL |
| Jeko-1 | 53.50 | MCL |
| HBL-2 | 33.04 | MCL |
| Z-138 | 25.46 | MCL |
| Rec-1 | 46.34 | MCL |
Cell lines derived from multiple lymphoma subtypes were incubated with LCL-161 for 48 hours at 37°C.
ABC-DLBCL, activated B-cell DLBCL; GCB-DLBCL, germinal center B-cell DLBCL.