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. 2019 Jan 3;37(1):113–122. doi: 10.1016/j.vaccine.2018.11.024

Fig. 5.

Fig. 5

T-cells from HIV-Infected individuals were capable of secreting high frequencies of SEB-stimulated T-cell responses. This figure summarizes the overall SEB-stimulated IFN-γ positive (blue) and negative (red) CD4+ T-cell responses, (A) The cells stratified into eight functional combinations of IFN-γ positive and negative cells, with bars representing frequencies (%) of expressed IL-2, TNF-α, and Perforin functions, and error bars the standard deviations. P values ≤ 0.05 are considered statistically significant, and are denoted with a * sign above the bars to indicate p-values ≤ 0.05; ** indicates p values ≤ 0.01 and *** indicates p values ≤ 0.001, (B) Pie charts summarize the proportions of functions in IFN-γ positive (upper C) and negative CD4+ T-cells (lower C). Pie arcs represent contributions of each function to the total response. Similarly, frequencies of IFN-γ positive and negative CD8+ T-cells are shown (D), distributed into eight profiles of functions (E), and summarized as pie charts and pie arcs, F.