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. 2018 Dec 10;4:677–687. doi: 10.1016/j.trci.2018.10.005

Fig. 2.

Fig. 2

High or low BCAA dietary intake modifies plasmatic and cerebral amino acids levels in 18-month-old 3xTg-AD mice. BCAA (Val, Leu, Ile) and AAA (Phe, Trp, Tyr, His) in intracardiac blood sampled just before perfusion, expressed as a ratio on total plasma amino acids (n = 4–6 per group) (A–C). BCAA and AAA in TBS-soluble fraction of cortex homogenates, expressed as a ratio on total protein content (n = 10–16 per group) (D–F). Data are presented as mean ± SEM. Two-way ANOVA, followed by Tukey's HSD; effect of the diet: &P < .05, &&P < .01, &&&&P < .0001; effect of BCAA: ε different from ctl, + different from high, • different from low. Abbreviations: CD, control diet; HFD, high-fat diet; ctl, normal levels of BCAA; high, BCAA-supplemented diet by 50%; low, BCAA-reduced diet by 50%; AAA, aromatic amino acid; BCAA, branched-chain amino acid.