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. 2018 Nov 7;293(48):18757–18769. doi: 10.1074/jbc.TM118.003336

Figure 1.

Figure 1.

Human MYC proteins. Shown is a schematic alignment of human c-MYC, MYCN, and MYCL. I–IV, MYC homology boxes I–IV; TAD, transactivation domain; NLS, nuclear localization signal; BR, basic region; HLH–LZ, helix-loop-helix–leucine zipper domain; aa, amino acid. Depicted are the longest RefSeq isoforms at NCBI_gene (https://www.ncbi.nlm.nih.gov/gene): NP_002458.2 (c-MYC IF1), NP_005369.2 (MYCN IF1), and NP_001028254.2 (MYCL IF3). Domains are assigned based on Ref. 32 for c-MYC, and combined NCBI_gene annotation and BlastP alignment (https://blast.ncbi.nlm.nih.gov/Blast.cgi) for the other MYC proteins.