Figure 1.

TRPS1 represses SOX2 expression. A, schematic diagram of the SOX2 gene with the GATA elements highlighted in its promoter region. B, expression of GATA factors in breast cancers from GEO. C, correlation between GATA factors and SOX2 in breast cancers from GEO. r, correlation coefficient. D, silencing TRPS1 increases SOX2 expression at both mRNA and protein level. All data are presented as the means ± S.D. of three independent experiments. The t test was used for statistic quantification. ***, p < 0.001.