Skip to main content
. 2018 Dec 12;38(50):10595–10606. doi: 10.1523/JNEUROSCI.1700-18.2018

Figure 2.

Figure 2.

Soluble WT tau aggregates, but not monomers or fibrils, potently inhibit LTP. A, Negative contrast electron micrographs of WT tau monomers, fibrils and SτAs. Scale bar, 100 nm. B, ThT binding (3 technical replicates in each group). C, Particle size distribution, peaking at ∼35 nm, for SτAs using DLS (average of 3 technical replicates). D, Time course graphs for the effects of vehicle (black diamonds; n = 5), WT monomers (25 pmol; open squares; n = 4), WT fibrils (20 pmol; gray circles; n = 4), or WT SτAs (1 pmol; gray triangles; n = 5) on the ability of HFS to induce LTP. E, Summary of the magnitude of potentiation at 3 h in groups shown in D. #p < 0.05, ##p < 0.01 (paired t test); ****p < 0.0001 (RM-2W-ANOVA, Dunnett test).