Table 3.
The Identified Significant KEGG Pathways in Different Modules
| DEGs/Modules | Pathways | Genes | p Value |
|---|---|---|---|
| Upregulated DEGs | |||
| Module 1 | Natural killer cell-mediated cytotoxicity | Tyrobp; Fcer1g; Rac2; Cd48 | 6.05E-05 |
| Fc γ R-mediated phagocytosis | Hck; Rac2; Ptprc | 0.0006 | |
| Osteoclast differentiation | Cybb; Tyrobp; Csf1r | 0.0017 | |
| Tuberculosis | Itgax; Fcer1g; Ctss | 0.0045 | |
| Regulation of actin cytoskeleton | Itgax; Nckap1l; Rac2 | 0.0080 | |
| Module 2 | MicroRNAs in cancer | Cd44;Pdgfrb;Vim | 0.0050 |
| Cytokine–cytokine receptor interaction | Cxcl9; Pdgfrb; Ccl5; Il2rg | 0.0003 | |
| HTLV-I infection | Pdgfrb; Vcam1; Il2rg | 0.0053 | |
| PI3K–Akt signaling pathway | Pdgfrb; Vwf; Il2rg | 0.0105 | |
| Module 3 | Leishmaniasis | Itgb2; Cyba; Jun | 2.39E-06 |
| Phagosome | Coro1a; Itgb2; Cyba | 4.41E-05 | |
| Downregulated DEGs | |||
| Module 1 | Retinol metabolism | Cyp1a2; Cyp2c70; Cyp2c54; Cyp2c44; Ugt2b1 | 2.30E-10 |
| Chemical carcinogenesis | Cyp1a2; Cyp2c70; Cyp2c54; Cyp2c44; Ugt2b1 | 3.60E-09 | |
| Metabolism of xenobiotics by cytochrome P450 | Cyp1a2; Cyp2c70; Cyp2c54; Cyp2c44; Ugt2b1 | 3.80E-09 | |
| Drug metabolism – cytochrome P450 | Cyp1a2; Cyp2c70; Cyp2c54; Cyp2c44; Ugt2b1 | 4.01E-09 | |
| Linoleic acid metabolism | Cyp2c54; Cyp1a2; Cyp2c44; Cyp2c70 | 7.36E-08 | |
| Arachidonic acid metabolism | Cyp2c44; Cyp2c54; Cyp2c70 | 1.59E-05 | |
| Serotonergic synapse | Cyp2c44; Cyp2c54; Cyp2c70 | 3.67E-05 | |