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. 2018 Dec 4;12:882. doi: 10.3389/fnins.2018.00882

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Copyright © 2018 Ryynänen, Toivanen, Salminen, Ylä-Outinen, Narkilahti and Lekkala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Noise in each MEA type and medium combination. (A) Estimation of the standard deviation of background noise of each MEA type and medium combination at two time points. Data are expressed as the median (band inside the box) with interquartile range (IQR; box) and minimum and maximum values (whiskers) at two time points: 6 and 18 days on MEA. BMT, BioMediTech MEA; MCS, Multi Channel Systems MEA; NDM, neuronal differentiation medium; BPH, BrainPhys medium. ***p ≤ 0.001. In addition, the noise level of BMT MEAs was significantly lower from that of MCS's sputtered TiN MEAs under the same time point and condition (p < 0.001 for all). (B) Examples of raw measurement data of each MEA type and medium combination at two time points. Curves have been shifted vertically for clarity.