Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 5;8:578. doi: 10.3389/fonc.2018.00578

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Lynes, Sanchez, Dominah, Nwankwo and Nduom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Peptide vaccine. (A) In the peptide vaccine, rindopepimut, EGFRvIII peptide is fused with highly immunogenic KLH (PEPvIII-KLH) for vaccine preparation. (B) The vaccine is administered intradermally and the antigen is recognized by APCs. (C) APCs present to T-cells and CTLs. (D) T-cells activate B-cells which then produce antibodies to EGFRvIII in the tumor. CTLs cross the blood brain barrier and target GBM cells with EGFRvIII on the surface. This activation of T-cells and CTLs results in anti-tumor response.