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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: J Autoimmun. 2018 Oct 17;95:47–57. doi: 10.1016/j.jaut.2018.09.010

Figure 3. Toll-like receptor 2 deficiency aggravated hepatic T-cell-mediated cholangitis in dnTGFβRII mice.

Figure 3

(A) Representative H&E staining of liver sections of female dnTGFβRII (TG) and dnTGFβRII TLR2−/− (TGT2) mice at 13–14 weeks of age. (B) Scores of portal inflammation in TG (n=11) and TGT2 (n=9) mice. (C) Scores of bile duct damage in TG (n=11) and TGT2 mice (n=9). (D) Absolute number of hepatic mononuclear cells from TG (n=6) and TGT2 (n=11) mice. (E) Cell numbers of total T cells and CD8+T and CD4+T cell subsets in the liver of TG (n=6) and TGT2 (n=11) mice analyzed by flow cytometry. (F) Frequency (left) and absolute number (right) of naive CD4+T (CD44-CD62L+) and effector memory CD4+T (CD44+CD62L-) cell subsets in the liver of TG (n=6) and TGT2 (n=11) mice. Data are presented as mean ± SD. *p<0.05, **p<0.01.