TABLE 3.
Effect of MTHFR rs3753584 variants on red blood cell folate concentrations in MTHFR 677 C→T variants (rs1801133)1
| Red blood cell folate (nmol/L), mean ± SD MTHFR rs3753584 | |||||
|---|---|---|---|---|---|
| AA | AG | GG | P value | ||
| Total | — | 1040 ± 422 | 1145 ± 430 | 1255 ± 467 | <0.00012 |
| (n = 1558) | (n = 599) | (n = 73) | |||
| MTHFR 677 | CC | 1096 ± 425 | 1151 ± 436 | 1255 ± 467 | 0.00433 |
| (n = 554) | (n = 362) | (n = 73) | |||
| MTHFR 677 | CT | 1048 ± 407 | 1136 ± 422 | NA | 0.00724 |
| (n = 745) | (n = 237) | (n = 0) | |||
| MTHFR 677 | TT | 897 ± 425 | NA | NA | |
| (n = 142) | (n = 0) | (n = 0) | |||
1 MTHFR, 5,10-methylenetetrahydrofolate reductase.
2Kruskal-Wallis test.
3Kruskal-Wallis test. In pairwise post-test comparisons that used Dunn's multiple comparison tests, only AA and GG differed significantly.
4Mann-Whitney U test.