TABLE 1.
Functional classification of DDX3 target genes
| KEGG pathway | P value | Genes |
|---|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | 3.66E−4 | P38γ, RAC1, MAP2K4, P38β, CCL5, ATP6V0A2, ATP6V0B |
| Toll-like receptor signaling pathway | 7.66E−4 | TAK1, P38γ, IRF7, RAC1, MAP2K4, P38β, CCL5, STAT1, PACT |
| MAPK signaling pathway | 9.88E−4 | TAK1, FGFR4, P38γ, ELK4, RRAS2, RAC1, MAP2K4, PRKACA, CACNB3, P38β, DUSP9, TGFB1 |
| American trypanosomiasis | 0.0036 | P38γ, PPP2CB, MAP2K4, P38β, GNAS, CCL5, TGFB1 |
| Oocyte meiosis | 0.0045 | ANAPC1, CCNE1, ANAPC5, PPP2R5B, PPP2CB, PRKACA, FBXW11 |
| Sphingolipid signaling pathway | 0.0072 | PRKCZ, PPP2R5B, P38γ, PPP2CB, RAC1, SPHK1, P38β |
| Dopaminergic synapse | 0.0098 | GNB2, PPP2R5B, P38γ, PPP2CB, PRKACA, P38β, GNAS |
| Shigellosis | 0.0130 | ATG5, P38γ, RAC1, P38β, FBXW11 |
| Herpes simplex virus infection | 0.0156 | TAK1, CSNK2A2, IFIT1, IRF7, IL15, CDC34, CCL5, STAT1 |
| RIG-I-like receptor signaling pathway | 0.0176 | TAK1, ATG5, P38γ, IRF7, P38β, PACT |
| TNF signaling pathway | 0.0177 | TAK1, P38γ, MAP2K4, P38β, IL15, CCL5 |
| Adherens junction | 0.0185 | TAK1, CSNK2A2, PARD3, RAC1, SSX2IP |
| Leishmaniasis | 0.0185 | TAK1, P38γ, P38β, STAT1, TGFB1 |
| Epstein-Barr virus infection | 0.0188 | TAK1, CSNK2A2, GTF2E2, P38γ, MAP2K4, PRKACA, P38β, POLR3E |
| Hippo signaling pathway | 0.0209 | PRKCZ, PARD3, NF2, PPP2CB, YAP1, FBXW11, TGFB1 |
| Pathways in cancer | 0.0243 | CCNE1, ARHGEF1, GNB2, RAC1, RALA, PRKACA, EGLN1, GNAS, STAT1, TGFB1, TRAF4, FH |
| Human T-cell lymphotropic virus 1 infection | 0.0299 | ANAPC1, ANAPC5, ELK4, RRAS2, MAP2K4, IL15RA, PRKACA, IL15, TGFB1 |
| Rap1 signaling pathway | 0.0305 | PRKCZ, FGFR4, PARD3, P38γ, RAC1, RALA, P38β, GNAS |
| Amyotrophic lateral sclerosis | 0.0344 | P38γ, RAC1, TOMM40, P38β |
| Progesterone-mediated oocyte maturation | 0.0357 | ANAPC1, ANAPC5, P38γ, PRKACA, P38β |
| Rheumatoid arthritis | 0.0370 | IL15, CCL5, TGFB1, ATP6V0A2, ATP6V0B |
| Influenza A | 0.0382 | P38γ, IRF7, MAP2K4, P38β, CPSF4, CCL5, STAT1 |
| Platelet activation | 0.0383 | PRKCZ, ARHGEF1, P38γ, PRKACA, P38β, GNAS |
| Osteoclast differentiation | 0.0394 | TAK1, P38γ, RAC1, P38β, STAT1, TGFB1 |
| Vibrio cholerae infection | 0.0399 | PRKACA, GNAS, ATP6V0A2, ATP6V0B |
| Tuberculosis | 0.0410 | P38γ, SPHK1, P38β, STAT1, TGFB1, ATP6V0A2, ATP6V0B |
| GnRH signaling pathway | 0.0411 | P38γ, MAP2K4, PRKACA, P38β, GNAS |
| mRNA surveillance pathway | 0.0411 | PPP2R5B, PPP2CB, CPSF6, CPSF4, PABPC1L |
| Hepatitis C | 0.0416 | IFIT1, P38γ, IRF7, PPP2CB, P38β, STAT1 |
| NOD-like receptor signaling pathway | 0.0437 | TAK1, P38γ, P38β, CCL5 |
| Ubiquitin-mediated proteolysis | 0.0463 | ANAPC1, ANAPC5, CDC34, SMURF1, FBXW11, STUB1 |
| Chemokine signaling pathway | 0.0501 | PRKCZ, PARD3, GNB2, RAC1, PRKACA, CCL5, STAT1 |