Table 3.
Various clinical parameters in low and high groups when miR-150 was estimated at D28
| Parameter | miR-150 at D28< 1 n=23 | miR-150 at D28> 1 n=8 | P value | |
|---|---|---|---|---|
| TLC x109/L initial | Median | 10 | 15.95 | 0.963 |
| Range | (1.2-242.3) | (1.68-65.35) | ||
| PLT x109/L | Median | 33 | 18 | 0.37 |
| Range | (2.0-208) | (9-290) | ||
| HB gm/dL | Median | 8.1 | 7.9 | 0.1 |
| Range | (5.9-12.1) | (4.8-9.1) | ||
| PB Blasts% | Median | 40 | 18.5 | 0.139 |
| Range | (4-94) | (0-65) | ||
| BM cellularity n(%) | Normocellular | 5 (21.7) | 1 (12.5) | 0.089 |
| Hypocellular | 2 (8.7) | 3 (37.5) | ||
| Hypercellular | 10 (43.5) | 4 (50) | ||
| Extrahypercellular | 6 (26.1) | 0 (0) | ||
| FAB n (%) | M0 | 1 (4.3) | 0 (0) | 0.084 |
| M1 | 4 (17.4) | 1 (12.5) | ||
| M2 | 10 (43.5) | 1 (12.5) | ||
| M3 | 2 (8.7) | 1 (12.5) | ||
| M4 | 5 (21.7) | 2 (25.0)0 (0) | ||
| M7 | 0 (0) | 0 (0) | ||
| Other | 1 (4.3) | 0 (0) | ||
| IPT n (%) | Myeloid | 15 (65.2) | 4 (50) | 0.030* |
| Myelomonocytic | 2 (8.7) | 0 (0) | ||
| Myeloid with aberrant | 4 (17.4) | 0 (0) | ||
| Myeloid B | 1 (4.3) | 0 (0) | ||
| Other | 1 (4.4) | 4 (50) | ||
| FLT-3 n (%) | Wild | 19 (82.6) | 7 (87.5) | 0.117 |
| Mutant | 4 (17.4) | 0 (0) | ||
| NA | 0 (0) | 1 (12.5) | ||
| Cytogenetics n (%) | t(8,21) | 2 (13.3) | 0 (0) | 0.524 |
| t(15,17) | 2 (13.3) | 0 (0) | ||
| Normal karyotype | 6 (40) | 4 (66.7) | ||
| Others | 5 (33.3) | 2 (33.3) | ||
| BM D28 cellularity n (%) | Normocellular | 9 (45) | 3 (37.5) | 0.817 |
| Hypocellular | 8 (40) | 3 (37.5) | ||
| Hypercellular | 3 (15) | 2 (25) | ||
| BM Blasts% D28 | Median | 25 | 2.5 | 0.69 |
| Range | (0-67) | (0-30) | ||
| Less than or equal 5 | 15 (75) | 6 (75) | ||
| More than or equal 6 | 5 (25) | 2 (25) | ||
| TLC x109/L at D28 | Median | 2.6 | 2.94 | 0.663 |
| Range | (0.1-16.3) | (0.38-16) | ||
| HB gm/dL at D28 | Median | 7.9 | 8 | 0.788 |
| Range | (3.3-10) | (6.9-10.3) | ||
| PLT x109/L at D28 | Median | 111.5 | 110 | 0.826 |
| Range | (2-558) | (5-579) | ||
| PB blasts % at D28 | Equal zero | 15 (71.4) | 7 (100) | 0.1 |
| More than or equal 1 | 6 (28.6) | 0 | ||
| Response to treatment | Refractory | 4 (18.2) | 2 (25) | 0.98 |
| CR | 18 (81.8) | 6 (71.475) | ||
| Relapse status | No relapse | 16 (84.2) | 3 (42.9) | 0.035* |
| Relapse | 3 (15.8) | 4 (57.1) | ||
| Early death | Before D28 | 2 (22.2) | 1 (100) | 0.13 |
| After D28 | 6 (75) | 0 (100) | ||
TLC: total leucocytic count, HB: hemoglobin, PLT: platelet count, PB: peripheral blood, BM: bone marrow, FAB: French American British classification, IPT: immunophenotyping, D28: day 28 of treatment, NA: non-available, CR: complete remission, OS: overall survival, RFS: Relapse-free survival.