Table 3.
Evaluations of immune protective response mediated by bacterial OMVs against infection in mice model
| Parent bacteria | Model establishment | OMVs administration | Adjuvant used | Efficiency | Immune response | References |
|---|---|---|---|---|---|---|
| E. coli | porcine pleuropneumonia | subcutaneous | aluminum | 87.5% survival for APP serotype 7 | Serum IgG Th1 and Th2 cytokines secretion | 93 |
| 62.5% survival for APP serotype 1 | ||||||
| S. Enteritidis | foodborne infections of S. Enteritidis | intranasal or intraperitoneal | none | 83.3% survival intranasally | Serum IgG and secretory IgA | 87 |
| 91% survival intraperitoneally | ||||||
| Salmonella enterica | Oral infection | Intranasally or intraperitoneally | none | 100% survival by Intraperitoneal immunization | Serum IgG and mucosal IgA | 94 |
| 80% survival by intranasal immunization | ||||||
| Neisseria meningitis | Infection | subcutaneous | aluminum hydroxide | 100% survival | Serum IgG | 95 |
| Neisseria meningitidis | Healthy neonatal mice | intranasal and subcutaneous | DODAB-BF and aluminum hydroxide | Not mentioned | IgG, Intranasal immunization, Th1 and Th2 response, | 96 |
| Th1 profile for subcutaneous immunization | ||||||
| P. gingivalis | Infection | intranasal | Poly (I:C) | Not mentioned | Serum IgG (including IgG1 and IgG2a) salivary S-IgA | 84 |
| K. pneumoniae | Sepsis | intraperitoneal | none | 80% survival with 0.5 μg OMVs and 100% survival with 1 μg OMVs | Serum IgG and the secretion of key cytokines of Th1 cells (IFN-γ) | 62 |
| B. pseudomallei | Septicemic infection | subcutaneous | none | 100% survival compared with40% survival in naive mice | serum IgG (IgG1, IgG2a, and IgG3) and IgM | 97 |
| Bordetella pertussis | Infection | intraperitoneal | none | Not mentioned | serum IgG, Th1 and Th17 response (the classic whole cell vaccine) | 98 |
| Th1/Th17 and Th2 mixed response (acellular vaccines) | ||||||
| V. cholerae | Infection | Oral immunization | none | > 80% protection | serum IgG, IgA, IgM, mucosal sIgA, Th2 and Th17 cell response | 99 |
| Shigella boydii | Infection | Oral immunization | none | 100% protection | mucosal IgG and IgA, Th1 cell response | 54 |
| B. abortus | Infection | subcutaneous | Freund’s complete and incomplete adjuvant | Not mentioned | Serum IgG, cellular immune response | 100 |
Abbreviations: E.coli, Escherichia coli; APP, Actinobacillus pleuropneumoniae; S. Enteritidis, Salmonella Enteritidis; Th, T helper;P. gingivalis, Porphyromonas gingivalis;Ig, immunoglobulin; K. pneumoniae, Klebsiella pneumoniae;B. pseudomallei, Burkholderia pseudomallei; V. cholerae, Vibrio cholerae; B. abortus, Brucella abortus; Infection means mice challenged with the same bacteria if not specific statement