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. 2018 Dec 12;6:19. doi: 10.1186/s40170-018-0192-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Transport-exclusion pharmacology to localize enzyme activity within a cell. a When the enzyme is localized to the cytosol, both inhibitors block activity. b When the enzyme is localized to mitochondria, only I_S blocks activity. E represents the enzyme of interest localized in cytosol or mitochondria. I_S represents an inhibitor of E that is transported into mitochondria. I_B represents an inhibitor of E that cannot be transported into mitochondria