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. 2018 Dec 12;6:19. doi: 10.1186/s40170-018-0192-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — TCA cycle labeling from U-¹³C lactate is decreased when whole cells are treated with oxamate, but not when whole cells are treated with GSK-2837808A. These results are consistent with oxamate (oxa) inhibiting cytosolic and mitochondrial LDH, but with GSK-2837808A (GSK) only inhibiting cytosolic LDH. HeLa cells were labeled with U-¹³C lactate for 24 h prior to analysis of whole-cell extracts by LC/MS. Data shown are averages from groups of n = 3. ***p < 0.001. n.s., no statistical significance. Left y axis shows labeling from 0 to 100%. Right y axis shows a zoomed-in scale for ¹³C isotopologues (inset)