The use of monoclonal antibodies (MoAbs) as a therapeutic option for metastatic colorectal cancer (mCRC) created expectations for greater overall survival as well as decreased toxicity and grade ≥ 3 adverse event complications compared with cytotoxic chemotherapy.

The results of the studies included in this meta-analysis showed increased overall survival, progression-free survival and metastasectomy rate in patients with mCRC using MoAbs; however, there was great heterogeneity in the studies and severe adverse events.

It is important to assess the value and cost of interventions for both first- and second-line treatments when making choices. Marginal gains with associated high costs are difficult to justify within universal healthcare systems.