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The 6606PDA syngeneic orthotopic pancreatic cancer model replicates features of human pancreatic cancer. 6606PDA cells were injected into the pancreas on day 0 and the chemotherapy started on day 4 (A). The tumor (white box or arrow) could be identified by 18F-FDG-PET/CT on day 35 (B,C) and 7 T MRI on day 34 (D). Tumors are surrounded by abundant collagen I deposition as indicated by double arrow (E). Bar = 1 cm in (C,D). Bar = 50 μm in (E).
