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Autophagy in CAFs attenuates the anti-proliferation activity of CHC and metformin (Met). Blocking autophagy in LTC cells (their proliferation was inhibited by pretreatment with MMC) with CQ significantly (shown in red) increased the sensitivity of pancreatic cancer cells to CHC (A), metformin (B), or CHC plus metformin (C). *P ≤ 0.0125.
