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. 2018 Dec 5;8:590. doi: 10.3389/fonc.2018.00590

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Copyright © 2018 Zhang, Schönrogge, Eichberg, Wendt, Kumstel, Stenzel, Lindner, Jaster, Krause, Vollmar and Zechner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autophagy in CAFs inhibits the anti-proliferative effect of gemcitabine (Gem). Co-culture with LTC cells (their proliferation was inhibited by pretreatment with MMC) significantly (shown in red) reduced the anti-proliferative effect of gemcitabine on 6606PDA cells (A) and MIA PaCa-2 cells (B). The pancreatic cancer cells were significantly (shown in red) more sensitive to gemcitabine, after inhibiting autophagy in LTC cells by CQ (C), or BAF (D). The present study demonstrates two points. First, CAFs impair the efficacy of chemotherapies. Second, blocking autophagy in CAFs supports the anti-proliferation activity of chemotherapeutic drugs (E). *P ≤ 0.0125.