Table 2.
Independent Associations Between Fraction of Small Adipose Cells and Inflammatory Genes, Adjusted for Insulin-Resistance Group and Gender*
Gene | Predictors | β ± SE | Standardized β | P value |
---|---|---|---|---|
TNF-α | Fraction small cells | 0.002 ± 0.10 | −0.003 | 0.98 |
IR group | 0.03 ± 0.02 | 0.19 | 0.22 | |
Gender | 0.03 ± 0.02 | 0.20 | 0.20 | |
iNOS | Fraction small cells | −0.44 ± 1.36 | −0.05 | 0.74 |
IR group | 0.06 ± 0.28 | 0.03 | 0.84 | |
Gender | 0.01 ± 0.29 | 0.008 | 0.96 | |
CD14 | Fraction small cells | −1.62 ± 0.63 | 0.33 | 0.01 |
IR group | 0.35 ± 0.13 | 0.37 | 0.009 | |
Gender | 0.07 ± 0.13 | 0.08 | .58 | |
CD45 | Fraction small cells | 2.29 ± 0.87 | 0.34 | 0.01 |
IR group | 0.46 ± 0.18 | 0.36 | 0.01 | |
Gender | −0.18 ± 0.18 | −0.14 | 0.31 | |
CD68 | Fraction small cells | 0.21 ± 0.64 | 0.04 | 0.74 |
IR group | 0.53 ± 0.73 | 0.55 | 0.0002 | |
Gender | −0.08 ± 0.14 | −0.08 | 0.58 | |
EMR-1 | Fraction small cells | 1.89 ± 0.74 | 0.33 | 0.01 |
IR group | 0.43 ± 0.15 | 0.39 | 0.007 | |
Gender | −0.14 ± 0.16 | −0.12 | 0.38 | |
IL-6 | Fraction small cells | 3.29 ± 1.51 | 0.28 | 0.04 |
IR group | 1.03 ± 0.31 | 0.45 | 0.002 | |
Gender | −0.05 ± 0.32 | −0.02 | 0.88 | |
IL-8 | Fraction small cells | 1.24 ± 1.14 | 0.13 | 0.28 |
IR group | 1.19 ± 0.23 | 0.63 | <0.0001 | |
Gender | −0.41 ± 0.24 | −0.22 | 0.09 | |
MCP-1 | Fraction small cells | 0.20 ± 0.06 | 0.38 | 0.003 |
IR group | 0.04 ± 0.01 | 0.40 | 0.003 | |
Gender | 0.003 ± 0.01 | 0.03 | 0.78 |
P-values are adjusted for gender and insulin resistance group via multiple linear regression analysis. Adjustment for BMI did not alter results.