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. 2018 Dec 12;1:226. doi: 10.1038/s42003-018-0236-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Clustering of 162 DHFR structures based on their pairwise Cα RMSD of the Met20 loops. DHFR structures are represented by circles filled in blue (humans), green (eDHFR), and red (in this study). The edge length (colored in purple for the occluded and gold for the closed conformations, respectively) is proportional to the maximum RMSD of the Met20 loop conformers. Please see a more detailed clustering diagram in the Supplementary Information