Table 3.

Clinicopathological factors associated with DFS in ICC patients.

Variable	Categorization	Univariate analysis	Multivariate analysis
		P value	HR	95% CI	P value
Sex	female, male	0.929
Age	≤56, >56	0.424
HBsAg	negative, positive	0.035*
intrahepatic biliary stones	negative, positive	0.421
Tumour diameter, cm	≤5, >5	0.193
Surgical procedure	nonanatomical, anatomical	0.607
Complications		0.250
No complication
Clavien-Dindo grade I-II
Clavien-Dindo grade III-IV
Tumour differentiation	poor, others	0.116
Vascular invasion	absent, present	0.074
Perineural invasion	absent, present	0.896
Periductal invasion	absent, present	0.852
Surgical margin	negative, positive	0.658
Lymph node metastasis	absent, present	0.119
Pathological cirrhosis	absent, present	0.629
antiviral therapy	no, yes	0.436
Adjuvant therapy	no, yes	0.006*	0.757	0.605–0.949	0.016*

* indicates statistically significant.

DFS, disease-free survival; HBsAg, hepatitis B virus surface antigen; HR, hazard ratio; ICC, intrahepatic cholangiocarcinoma.