Table 4.

Clinicopathological factors associated with OS in ICC patients.

Variable	Categorization	Univariate analysis	Multivariate analysis
		P value	HR	95% CI	P value
Sex	female, male	0.526
Age	≤56, >56	0.630
HBsAg	negative, positive	0.026*
intrahepatic biliary stones	negative, positive	0.501
Tumour diameter, cm	≤5, >5	0.106
Surgical procedure	nonanatomical, anatomical	0.477
Complications		0.154
No complication
Clavien-Dindo grade I-II
Clavien-Dindo grade III-IV
Tumour differentiation	poor, others	0.266
Vascular invasion	absent, present	0.007*
Perineural invasion	absent, present	0.468
Periductal invasion	absent, present	0.142
Surgical margin	negative, positive	0.844
Lymph node metastasis	absent, present	0.011*	1.972	1.039–3.743	0.038*
Pathological cirrhosis	absent, present	0.389
antiviral therapy	no, yes	0.979
Adjuvant therapy	no, yes	0.550

* indicates statistically significant.

HBsAg, hepatitis B virus surface antigen; HR, hazard ratio; ICC, intrahepatic cholangiocarcinoma; OS, overall survival.