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. 2018 Dec 12;9:5232. doi: 10.1038/s41467-018-07698-6

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© The Author(s 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CL27c reduces inflammation in a model of OVA-induced acute allergic asthma. a Protocol of OVA-induced acute allergic asthma and treatment regimen with inhaled CL27c (2 mg/ml) or Dexamethasone (Dexa, 3 mg/kg, i.p.). b Quantification of macrophage, neutrophil, eosinophil, and lymphocyte infiltration in BALF of control and OVA-treated mice in the presence of vehicle (white bars), CL27c (black bars) or Dexa (gray bars) (from left to right, macrofages n = 6, 6, 10, 6, neutrophils n = 6, 6, 10, 5, eosinophils n = 6, 6, 8, 5, and lymphocytes n = 6, 5, 10, 6 independent experiments, respectively). c Analysis of IL-5 and IL-13 levels in the lung tissue of control and OVA-treated mice in the presence of vehicle, CL27c or Dexa (from left to right IL-5 n = 5, 11, 9, 5 and IL-13 n = 5, 11, 10, 5 independent experiments, respectively). d Histopathological analysis of lung of peribronchial (upper panels) and alveolar (lower panels) spaces showing CD18⁺ leukocyte infiltration (brown cells) in CL27c or Dexamethasone (Dexa)-treated mice after the OVA challenge. Bar = 50 μm (upper panel) and 10 μM (lower panel). Results represent mean ± s.e.m., *P < 0.05, **P < 0.01, ***P < 0.001 determined using one-way ANOVA followed by Bonferroni post-hoc test. n.s. = non-significant (P > 0.05)