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Pharmacokinetics of aerosolized CL27c
| Hours from exposure | 0.2 mg/ml CL27c | 2 mg/ml CL27c | |||
|---|---|---|---|---|---|
| CL27c | CL27e | CL27c | CL27e | ||
| Lung (ng/g) | 1 | 32.6 ± 5.1 | n.d. | 169.2 ± 17.7 | 4.5 ± 1.0 |
| 3 | 10.9 ± 0.5 | n.d. | 34.2 ± 5.2 | 0.1 ± 0.1 | |
| 6 | 10.9 ± 1.8 | n.d. | 41.6 ± 6.5 | 0.5 ± 0.2 | |
| Plasma (ng/ml) | 1 | n.d. | n.d. | 1.2 ± 0.1 | 1.34 ± 0.62 |
| 3 | n.d. | n.d. | n.d. | <1 | |
| 6 | n.d. | n.d. | n.d. | <1 | |
Values are the mean of at least three animals. n.d. not determined
