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Effects of amiloride 4, 18, and 26 in experimental mouse model of late-stage lung metastasis. All compounds were administered once daily at 7.5 mg kg−1 day−1 for 21 days. Lung metastasis was quantified by end point luciferase assay of lung homogenates. Data represent the mean ± SEM (18 and 26 n = 6; vehicle and 4 n = 4): (∗) p < 0.03; (∗∗∗) p < 0.001 relative to vehicle control, (∧) p < 0.03 relative to 4.
