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. Author manuscript; available in PMC: 2019 Sep 27.
Published in final edited form as: J Med Chem. 2018 Sep 7;61(18):8299–8320. doi: 10.1021/acs.jmedchem.8b00838

Figure 3.

Figure 3.

X-ray cocrystal structures of (a) amiloride 449 (PDB code 1F5L) and (b) HMA 5 (PDB code 5ZA7, 1.7 Å resolution) bound to uPA. Blue wire basket = 2mFo − DFC map contoured at 1.5σ.