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. Author manuscript; available in PMC: 2018 Dec 12.
Published in final edited form as: ACS Biomater Sci Eng. 2018 Feb 3;4(3):900–918. doi: 10.1021/acsbiomaterials.7b00831

Figure 11.

Figure 11

Immunophenotypic changes in MP-treated DCs vary with the molecular weight of PLGA molecular weight. Briefly, DCs were cocultured with PLGA MPs of higher molecular weight (5004A and 5010) for time points ranging from 6 to 120 h. The composite maturation indexes (unweighted average of the expression of CD80, CD86, and MHCII) of DCs at each time point are shown, normalized to the iDC population. The larger molecular weight polymers 5004A and 5010 do not provide immunosuppressive effects but rather maintain a CMI similar to that of immature dendritic cells. Immature DCs and LPS-stimulated DCs (1.5 μg/mL) serve as negative and positive controls, respectively. PLG50-treated cells serve as a reference to prior experiments. Pair-wise significant differences from the iDC population are denoted by the * symbol (p ≤ 0.05; n = 3 biological replicates). Data shown represent the mean ± standard error.