Table 2.
Patient Outcomes by Hospital Quartile of Compliance with the 3-Hour and 6-Hour Bundles
| First (Lowest) | Second | Third | Fourth (Highest) | P Value* | |
|---|---|---|---|---|---|
| Quartiles of 3-h bundle compliance† | |||||
| Patients, n | 18,915 | 19,634 | 17,232 | 18,512 | |
| Risk-adjusted hospital mortality, % (95% CI) | 29.8 (29.2–30.4) | 26.2 (25.6–26.8) | 25.9 (25.3–26.5) | 23.5 (22.9–24.1) | <0.001 |
| Median (IQR) hospital LOS for those that survived, d | 263 (158–463) | 257 (148–453) | 232 (142–401) | 199 (124–336) | <0.001 |
| Quartiles of 6-h bundle compliance† | |||||
| Patients, n | 19,038 | 18,377 | 18,441 | 18,437 | |
| Risk-adjusted hospital mortality, % (95% CI) | 28.4 (27.8–29.0) | 27.7 (27.1–28.3) | 25.9 (25.3–26.4) | 23.4 (22.9–24.0) | <0.001 |
| Median (IQR) hospital LOS for those that survived, d | 247 (149–432) | 259 (151–455) | 220 (136–383) | 217 (130–377) | <0.001 |
Definition of abbreviations: CI = confidence interval; IQR = interquartile range; LOS = length of stay.
*
Risk-adjusted hospital mortality is based on chi-square test of trend, and hospital LOS is based on the nonparametric equality-of-medians test.
†
The quartiles of probability of bundle compliance are based on two individual unadjusted random-effects logistic regression models where hospital is the random term. Only patients with a sepsis protocol initiated were included in the model (n = 72,293).