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. 2018 Dec 1;198(11):1423–1434. doi: 10.1164/rccm.201710-2079OC

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Figure 6. — Treatment with a HIF-2α (hypoxia-inducible factor-2α) inhibitor prevents right heart failure and cardiac fibrosis in Sugen 5416/hypoxia (SuHx) rats. (A) C76 (compound 76) treatment inhibited right ventricular (RV) hypertrophy. (B and C) Echocardiography demonstrating decreased RV wall thickness (B) and restored RV contractility (C) in C76-treated SuHx rats. (D) Representative micrographs and quantification of trichrome staining demonstrating reduction in RV fibrosis by C76 treatment in SuHx rats. Blue indicates collagen deposition. *P < 0.05, **P < 0.01, and ***P < 0.001. (A–C) One-way ANOVA with Tukey post hoc analysis for multiple group comparisons. (D) Mann-Whitney test. (D) Scale bar: 50 μm. RV FAC = right ventricular fractional area change; RV/(LV + S) = ratio of right ventricle to left ventricle plus interventricular septum; RV WTD = RV wall thickness during diastole.