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. 2018 Nov 27;9(93):36613–36624. doi: 10.18632/oncotarget.26400

Table 1. Prognostic significance of MRD in NPM1mut AML by univariate and multivariate Cox analysis.

Univariate Cox analyses
Overall Survival (OS) Relapse Free Survival (RFS)
HR (95% CI) P HR (95% CI) P
NGS MRD 0.002 0.0001
MRD Negative 1 1
MRD Positive 3.74 (1.64 to 8.54) 4.5 (2.2 to 9.86)
PI FCM-MRD 0.0081 0.012
MRD Negative 1 1
MRD Positive 2.6 (1.29 to 5.27) 2.3 (1.2 to 4.26)
PC FCM-MRD 0.26 0.5
MRD Negative 1 1
MRD Positive 1.84 (0.65 to 5.30) 1.42 (0.51 to 3.92)
FLT3-ITD 0.83 0.96
FLT3-ITD Negative 1 1
FLT3-ITD Positive 1.08 (0.53 to 2.23) 1.02 (0.53 to 1.94)
DNMT3A 0.0330 0.08
DNMT3A Negative 1 1
DNMT3A Positive 2.53 (1.08 to 5.93) 2.08 (0.92 to 4.70)
Multivariate Cox analyses
Overall Survival (OS) Relapse Free Survival (RFS)
HR (95% CI) P HR (95% CI) P
NGS MRD 3.64 (1.58 to 8.37) 0.0025 4.8 (2.24 to 10.28) 0.0001
PI FCM-MRD 2.61 (1.14 to 6.00) 0.0246 2.71 (1.27 to 5.8) 0.0105

Abbreviations: HR, hazards ratio; CI, confidence interval; ITD, internal tandem duplication.