Table 1. Prognostic significance of MRD in NPM1mut AML by univariate and multivariate Cox analysis.
| Univariate Cox analyses | ||||
|---|---|---|---|---|
| Overall Survival (OS) | Relapse Free Survival (RFS) | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| NGS MRD | 0.002 | 0.0001 | ||
| MRD Negative | 1 | 1 | ||
| MRD Positive | 3.74 (1.64 to 8.54) | 4.5 (2.2 to 9.86) | ||
| PI FCM-MRD | 0.0081 | 0.012 | ||
| MRD Negative | 1 | 1 | ||
| MRD Positive | 2.6 (1.29 to 5.27) | 2.3 (1.2 to 4.26) | ||
| PC FCM-MRD | 0.26 | 0.5 | ||
| MRD Negative | 1 | 1 | ||
| MRD Positive | 1.84 (0.65 to 5.30) | 1.42 (0.51 to 3.92) | ||
| FLT3-ITD | 0.83 | 0.96 | ||
| FLT3-ITD Negative | 1 | 1 | ||
| FLT3-ITD Positive | 1.08 (0.53 to 2.23) | 1.02 (0.53 to 1.94) | ||
| DNMT3A | 0.0330 | 0.08 | ||
| DNMT3A Negative | 1 | 1 | ||
| DNMT3A Positive | 2.53 (1.08 to 5.93) | 2.08 (0.92 to 4.70) | ||
| Multivariate Cox analyses | ||||
|---|---|---|---|---|
| Overall Survival (OS) | Relapse Free Survival (RFS) | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| NGS MRD | 3.64 (1.58 to 8.37) | 0.0025 | 4.8 (2.24 to 10.28) | 0.0001 |
| PI FCM-MRD | 2.61 (1.14 to 6.00) | 0.0246 | 2.71 (1.27 to 5.8) | 0.0105 |
Abbreviations: HR, hazards ratio; CI, confidence interval; ITD, internal tandem duplication.