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. 2018 Nov 27;9(93):36561–36574. doi: 10.18632/oncotarget.26337

Figure 6. Effect of losartan (LOS) on tumor of OSCC cells in nude mice.

Figure 6

(A) Effect of LOS on intracellular RAS in OSCC tumors. HSC3 or HSC4 cells were inoculated into the back of nude mice (n = 6 in each group). Mice were treated with 5-FU (5 mg/kg body weight) and/or LOS (20 mg/Kg body weight) twice a week for two weeks. In LOS-treated tumors after 40 days, we measured AGTR2 mRNA expression, and the protein levels of nuclear AGTR2 and RAS-associated proteins. (B and C) Effect of LOS on tumor growth of HSC3 and HSC4 cells, respectively, in nude mice. (D) Intratumoral A-II concentration, Proliferation (Ki-67), apoptosis (TUNEL), oxidative stress (4-HNE) and redox status (GSH/GSSG) in the tumors treated with 5-FU or 5-FU+LOS and untreated tumors. Error bar, S.D. Asterisk, statistical difference between 5-FU-treated mice and 5-FU+LOS-treated mice.