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Mechanisms for EphA4-mediated stimulation of platelet aggregation. Activation of EphA4 through binding to its ligand, ephrin-B1, on adjacent platelets may increase their adhesion via several pathways. These include formation of a protein complex leading to activation of the cell adhesion molecule L1; promotion of integrin alphaIIbeta3-mediated adhesion via Rap1B activation; or direct stimulation of integrin alphaIIbeta3 binding to myosin, leading to clot retraction.
