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. Author manuscript; available in PMC: 2018 Dec 12.
Published in final edited form as: Front Biosci (Landmark Ed). 2012 Jan 1;17:473–497. doi: 10.2741/3939

Figure 5.

Figure 5.

A model of EphB forward signaling regulating cell-cell repulsion and cell architecture. EphB4 forward signaling mediates cell-cell repulsion via both Rho-ROCK and Cdc42-MRCK mediated actomyosin contractility. EphB2 regulates spine morphogenesis by interacting with Intersectin and activating it along with N-Wasp, thereby activating Cdc42. EphB2 stimulation by ephrin-B phosphorylates Tiam1 and recruits it to EphB, which in turn stimulates Rac1 dependent actin remodeling, leading to spine formation.