Skip to main content
. Author manuscript; available in PMC: 2018 Dec 12.
Published in final edited form as: Front Biosci (Landmark Ed). 2012 Jan 1;17:473–497. doi: 10.2741/3939

Table 1.

Effects of EphA forward signaling on cell-ECM adhesion in different cell types

Cell type Ligand/ receptor Effect of EphA forward signaling on cell-ECM adhesion Proposed mechanism Reference
Neurons (dendritic spines) EphA4/ ephrin-A3 ⇓ Activation of SPAR (Rap1 GAP), leading to integrin inactivation (Figure 3) 115, 17, 135
Prostatic carcinoma
(PC-3)		 EphA2/ ephrin-A1 ⇓

  1. Inhibition of Rac leading to loss of lamellipodia/reduced integrin recruitment to lamellipodia/reduced ROS levels and cell retraction.

  2. Regulation of integrin structure.

  3. Inhibition of focal adhesions via FAK / paxillin dephosphorylation.

 22, 111, 145
Vascular smooth muscle cells (VSMCs) EphA2/ ephrin-A1 ⇓ Inhibition of Rac leading to loss of lamellipodia/reduced integrin recruitment to lamellipodia. 43
NIH 3T3 cells

  1. EphA2/ ephrin-A1

  2. EphA8/ ephrin-A5

 ⇑

  1. FAK/p130cas phosphorylation, promoting focal adhesions.

  2. Membrane recruitment of p110γ PI3 kinase, leading to promotion of integrin function.

 24

66
Astrocytes EphA4/ ephrin-A5 ⇑

  1. Increased focal adhesions.

  2. Activation of Rho via Vav1/2 (RhoGAP) inhibition (?).

 133
Langerhans cells EphA2, EphA4 & EphA/ ephrin-A3 & ephrin-B1 ⇑ Integrin activation. 41