Table 4. Adjusted association between major adverse cardiac events (MACE)^a, CAC, SIS, and baseline statin therapy^b.

	Overall population		Without statin therapy		With statin therapy
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
CAC 0	1.00		1.00		1.00
CAC 1–99	1.62 (1.07–2.45)	0.022	2.15 (1.30–3.56)	0.003	0.76 (0.36–1.59)	0.462
CAC 100–299	2.64 (1.60–4.37)	<0.001	2.54 (1.28–5.01)	0.007	2.16 (1.03–4.55)	0.042
CAC ≥300	4.63 (2.87–7.45)	<0.001	4.91 (2.65–9.11)	<0.001	3.84 (1.81–8.13)	<0.001
SIS 0	1.00		1.00		1.00
SIS 1	2.22 (1.43–3.47)	<0.001	1.82 (1.02–3.24)	0.043	2.65 (1.30–5.43)	0.008
SIS 2–3	2.84 (1.85–4.37)	<0.001	3.13 (1.86–5.27)	<0.001	1.95 (0.91–4.18)	0.088
SIS ≥4	3.48 (2.18–5.55)	<0.001	3.19 (1.75–5.82)	<0.001	3.54 (1.67–7.48)	0.001

CAC, coronary artery calcium; SIS, segment involvement score.

^aMACE was defined as a composite of all-cause mortality, myocardial infarction, unstable angina, target vessel revascularization, and coronary artery disease-related hospitalization

^bAdjusted for age, male gender, hypertension, diabetes mellitus, dyslipidemia, family history and current smoking.