Table 2. Multivariate analysis of factors associated with survival in REAL3.

Variable	p value MANOVA Overall survival	p value MANOVA Progression free survival
Age (<=65 (44), >65 (29))	0.83	0.64
Gender (M (7), F (67))	0.18	0.35
Tumour Site (O, S, OGJ)	0.61	0.98
Disease extent (locally advanced (7), metastatic (67))	0.04	0.01
WHO PS 0 (28), >0 (33), unknown (3)	0.23	0.25
Histological subtype (Intestinal (61), diffuse (7), Mixed (5), Unknown (1))	0.13	0.03
Treatment (EOX (38), EOX-P (36))	0.37	0.67