Table 1. Demographic and clinical data of the overall population.
| Not intubated at min 10 N = 316 |
Intubated at min 10 N = 63 |
p | N | |
|---|---|---|---|---|
| Gestational age (weeks) | 28.3 [27.0;29.1] | 27.0 [25.7;28.1] | <0.001 | 379 |
| Birthweight (g) | 1060 [849;1226] | 910 [788;1090] | 0.007 | 379 |
| Birthweight (z Score) | -0.02 [-0.52;0.56] | 0.09 [-0.42;0.61] | 0.592 | 379 |
| Boys | 174 (55.1%) | 35 (55.6%) | 1 | 379 |
| Multiple births | 104 (32.9%) | 26 (41.3%) | 0.258 | 379 |
| Pre-eclampsia | 85 (26.9%) | 11 (17.5%) | 0.157 | 379 |
| Preterm Labor | 195 (61.7%) | 46 (73.0%) | 0.119 | 379 |
| Premature rupture of membranes | 76 (24.1%) | 16 (25.4%) | 0.947 | 379 |
| Chorio-amnionitis | 62 (19.6%) | 21 (33.9%) | 0.021 | 378 |
| Prenatal steroids | 290 (91.8%) | 49 (77.8%) | 0.002 | 379 |
| Caesarean section | 208 (65.8%) | 39 (61.9%) | 0.652 | 379 |
| 1-min Apgar Score | 7.00 [5.00;8.25] | 2.00 [1.00;3.50] | <0.001 | 379 |
| Respiratory support at birth (before hour 2): | <0.001 | 379 | ||
| InSurE | 5 (1.58%) | 1 (1.59%) | ||
| InVent | 129 (40.8%) | 62 (98.4%) | ||
| LISA | 128 (40.5%) | 0 (0.00%) | ||
| nCPAP | 54 (17.1%) | 0 (0.00%) | ||
| Surfactant therapy | 276 (87.3%) | 62 (98.4%) | 0.018 | 379 |
| Duration of first ventilation associated with surfactant administration | 0.25 [0.00;24.0] | 47.9 [17.9;192] | <0.001 | 325 |
| Mechanical ventilation | 208 (65.8%) | 57 (90.5%) | <0.001 | 379 |
| Mechanical ventilation on day 3 | 84 (26.7%) | 32 (57.1%) | <0.001 | 371 |
| Duration of mechanical ventilation (days) | 1.00 [0.00;8.00] | 5.00 [1.00;22.0] | <0.001 | 377 |
| Any respiratory support (mechanical ventilation or CPAP) (days) | 43.0 [25.0;65.0] | 42.0 [16.2;79.5] | 0.769 | 374 |
| Air leak | 8 (2.54%) | 9 (15.5%) | <0.001 | 373 |
| Supplemental O2 at 28 days postnatal age | 227 (77.2%) | 39 (83.0%) | 0.486 | 341 |
| Grade I/II/III BPD | 113 (44.1%) | 21 (51.2%) | 0.209 | 327 |
| Early Onset Sepsis | 2 (0.64%) | 2 (3.45%) | 0.116 | 372 |
| Late Onset Sepsis | 68 (21.8%) | 11 (20.4%) | 0.956 | 366 |
| Grade 3 or 4 intraventricular haemorrhage | 30 (9.68%) | 16 (29.1%) | <0.001 | 365 |
| White matter damage | 34 (10.8%) | 14 (22.2%) | 0.022 | 379 |
| Cystic periventricular leukomalacia | 10 (3.16%) | 0 (0.00%) | 0.380 | 379 |
| Surgical treatment of necrotising enterocolitis or focal intestinal perforation | 7 (2.24%) | 3 (5.56%) | 0.170 | 367 |
| Laser of retinopathy of prematurity | 11 (3.89%) | 4(9.52%) | 0.114 | 325 |
| Surgical treatment of patent ductus arteriosus | 32 (10.3%) | 9 (16.7%) | 0.252 | 366 |
| Death before discharge | 24 (7.67%) | 22 (34.9%) | <0.001 | 376 |
| Death or grade I/II/III BPD | 137 (43.9%) | 43 (68.3%) | 0.001 | 375 |
| Death or major morbidities | 146 (46.9%) | 45 (71.4%) | 0.001 | 374 |
| Death or major morbidities including ROP | 152 (49.4%) | 45(71.4%) | 0.002 | 371 |
Data are presented as n (%) or the median [1st quartile; 3rd quartile]. InVent: intubation with tracheal ventilation for 1 h or more; InSurE: intubation with surfactant administration and tracheal ventilation for less than 1 h; LISA: less invasive surfactant administration; nCPAP: no surfactant administration during the first 2 h of neonatal care.